Plinest

Polynucleotides
Unlocking Radiant Skin.

Polynucleotides are biopolymers composed of nucleotide monomers. They are essentially long chains of nucleotides, which are the building blocks of DNA and RNA. These molecules have various roles in the body, including cellular repair and regeneration. In aesthetic treatments, polynucleotides are used for their regenerative properties, helping to skin quality by promoting cell turnover and healing.


This treatment helps to stimulate natural regenerative processes, to improved skin texture, elasticity, and hydration.


It is also great for people who want to the signs of ageing on the skin.

What are Polynucleotides?

are long chains of nucleotides, which are the building blocks of DNA and RNA. These molecules are derived from salmon DNA, which has been found to be highly biocompatible with human tissue.


The treatment works at a cellular level to stimulate tissue repair, promote collagen production, and improve overall skin quality.

Key benefits of Polynucleotides

Polynucleotides treatments offer numerous advantages for skin health and appearance:


Improved skin texture and tone


Reduction in fine lines and wrinkles


Enhanced skin firmness and elasticity


Brighter, more radiant complexion


Reduction in pigmentation and dark circles (particularly around the eyes)


Minimised appearance of scars and stretch marks


Overall skin rejuvenation

Polynucleotides Packages:

Per area: £350


Per area: £600


Per area: £850

FAQs



Which areas can be treated with polynucleotides?






At Karwal Aesthetics, we offer Plinest polynucleotides for various areas of the face and body:


Face: Mid-face and lower face


Eyes: Under-eye area, crow's feet, upper eyelids


Neck and décolletage: For addressing crepey skin and horizontal lines


Hands: To improve skin quality and reduce visible signs of ageing




How many polynucleotide sessions are needed?






The number of treatments varies depending on individual concerns and goals:


Initial course: Typically 2-4 sessions spaced 2-4 weeks apart


Maintenance: Follow-up treatments every 6 months to maintain results


Severe concerns: May require more intensive treatment protocols




When will I see results from polynucleotides?






Results from Plinest polynucleotide develop gradually:


Immediate: Some and subtle glow may be visible straight away


2-4 weeks: Noticeable improvements in skin texture and tone


4-8 weeks: More significant improvements as collagen production increases


3-6 months: Optimal results become apparent


Results typically last 6-12 months, depending on individual factors such as age, lifestyle, and skin condition.




Who is suitable for polynucleotides treatment?






Polynucleotides are suitable for most adults looking to improve their skin quality. Ideal candidates include those who:


Have early to moderate signs of ageing


Want natural-looking rejuvenation without fillers


Have sun-damaged or dehydrated skin


Are looking for preventative anti-ageing treatments


Have realistic expectations about results




Where do we offer polynucleotides?






We offer polynucleotide treatments at our clinic in London Mayfair. Our practice is conveniently located in the heart of Mayfair, one of London's most prestigious areas, making it easily accessible for clients across the capital.



Clinic Location


Address: 15 Dover Street, London, W1S 4LP


Our Mayfair clinic provides a luxurious and environment where you can receive your Plinest treatments from Dr Arun, an experienced aesthetic practitioner. The clinic is equipped with modern facilities and adheres to the highest standards of safety and hygiene.



How to Find Us


By Underground: Green Park station (Jubilee, Piccadilly, and Victoria lines) is just a short walk away


By Bus: Multiple bus routes serve the Mayfair area


By Car: Limited street parking available; several car parks nearby



To book your polynucleotides consultation or treatment, .




Benefits of Plinest Eyes Polynucleotides






Skin Texture: The treatment helps to smooth out fine lines and wrinkles, giving the skin a more refined texture.


Enhanced Elasticity: By boosting collagen production, Plinest Eyes improves skin elasticity, making it more resilient and firm.


Increased Hydration: The help to maintain moisture levels in the skin, preventing dryness and dullness.


Natural-Looking Results: The regenerative properties of polynucleotides provide a subtle and natural enhancement, avoiding the overly artificial look that some treatments can produce.


Minimal Downtime: Plinest Eyes is a minimally invasive procedure with little to no downtime, allowing individuals to resume their daily activities shortly after treatment.




What is the aftercare with Plinest?






Aftercare Notes for Sunekos, Profhilo & Plinest:


Needle entry points, redness, bruising, swelling and asymmetry around injection sites immediately after treatment is normal due to the very nature of the treatment.


There may also be some tenderness present as the bruising and inflammation sets in. These symptoms will resolve over the next 2-7 days, depending on your individual response to the treatment.


For 24 hours avoid:


Touching your face


Applying makeup


Skincare with active ingredients


No alcohol


No exercise


No hot showers or sauna/steam rooms





Plinest vs. Sunekos






Both Plinest and Sunekos are bio-revitalisation treatments, but they differ in their composition and mechanisms of action. Sunekos contains a patented formula of hyaluronic acid combined with a specific blend of amino acids, whilst Plinest uses polynucleotides derived from salmon DNA.


Key differences include:


Active ingredients: Sunekos relies on hyaluronic onabotulinumtoxinaabobotulinumtoxinaincobotulinumtoxinaprabotulinumtoxinaletibotulinumtoxinarimabotulinumtoxinbhyaluronic acid fillerscalcium hydroxylapatite fillerspoly-l-lactic acid fillerspolymethylmethacrylate fillersautologous fat graftingforehead lines treatmentglabellar frown lines treatmentcrow's feet treatmentbunny lines treatmentchemical brow liftlip flipgummy smile correctionmasseter reductionjaw slimmingdimpled chin smoothingcobblestone chin Smoothingnefertiti neck liftmicro-botoxmesotoxhyperhidrosis treatmentchronic migraine reliefbruxism treatmenttmj treatmentcervical dystonia treatmentneck spasm treatmentblepharospasm treatmentlip augmentationlip contouringcheekbone enhancementtear trough fillersnasolabial fold softeningmarionette line fillersliquid rhinoplastynon-surgical nose jobjawline contouringjawline definitionchin augmentationtemple volumisinghand rejuvenationacne scar subcision filling and amino acids to stimulate the extracellular matrix, Plinest uses polynucleotides for cellular regeneration and tissue repair.


Mechanism: Sunekos works by providing the building blocks for collagen and elastin synthesis, whilst actively fibroblast activity and has additional anti-inflammatory and antioxidant properties.


Treatment areas: Both can be used on similar areas, though Plinest Eye is specifically formulated for the periorbital region, whilst Sunekos has different formulations (Sunekos 200 and Sunekos 1200) for varying levels of skin laxity.


Results: Both provide natural-looking improvements. However, is the preferred product at Karwal Aesthetics, delivering more dramatic results and better improvement in hyperpigmentation, fine lines, and skin texture—especially crepey skin.




Plinest vs. Profhilo






Both Plinest and are bio-remodelling that stimulate natural skin rejuvenation, but they differ in their and approach:


Active ingredients: Profhilo contains highly concentrated hyaluronic acid (HA), whilst Plinest uses polynucleotides derived from salmon DNA.


Mechanism of action: Profhilo works through bio-remodelling with HA to and elastin production in four different types of collagen. Plinest works by directly stimulating fibroblast activity and has additional anti-inflammatory and antioxidant properties.


Injection technique: Profhilo uses the BAP (Bio Points) technique with 5 injection points per side of the face, whilst Plinest requires multiple injection points distributed across the treatment area.


Spread: Profhilo's unique formulation allows it to spread more easily under the skin after injection, whilst Plinest remains more localised to the sites.


Hydration vs. regeneration: Profhilo primarily focuses on intense hydration and bio-remodelling, whilst Plinest emphasises cellular regeneration, tissue repair, and anti-inflammatory effects.


Treatment areas: Both can be used on similar areas, though Profhilo is particularly noted for its lifting and hydrating effects on the face and neck, whilst Plinest offers targeted like Plinest Eye for concerns.


Results: Both provide natural-looking improvements. However, Profhilo is the preferred product at Karwal Aesthetics between the two. Profhilo delivers a natural glow, plumpness, and hydration to the skin.




Potential side effects






Plinest polynucleotide treatments are well-tolerated, but some temporary side effects may occur:


Mild at sites


Slight bruising (more common in sensitive areas)


Redness or tenderness


Small bumps at injection points


These effects typically resolve within hours. side effects are rare when performed by qualified practitioners.








Business Enquiries





Mayfair, London
2nd Floor, 15 Dover Street, W1S 4LP


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0% finance is available on all treatments from £500. Find out more by visiting our Payment Plan page.


Please note: our clinic is on the second floor with stair access only.


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